James F Howard Selected Research

Myasthenia Gravis

10/2021	Cellular changes in eculizumab early responders with generalized myasthenia gravis.
9/2021	A Case of MuSK Myasthenia Gravis Presenting With Persistent Respiratory Insufficiency.
5/2021	Zilucoplan: An Investigational Complement C5 Inhibitor for the Treatment of Acetylcholine Receptor Autoantibody-Positive Generalized Myasthenia Gravis.
1/2021	Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension.
1/2021	Long-term efficacy of eculizumab in refractory generalized myasthenia gravis: responder analyses.
1/2021	Safety, efficacy, and tolerability of efgartigimod in patients with generalised myasthenia gravis (ADAPT): a multicentre, randomised, placebo-controlled, phase 3 trial.
7/2020	'Minimal symptom expression' in patients with acetylcholine receptor antibody-positive refractory generalized myasthenia gravis treated with eculizumab.
1/2020	Consistent improvement with eculizumab across muscle groups in myasthenia gravis.
1/2020	Clinical features of LRP4/agrin-antibody-positive myasthenia gravis: A multicenter study.
1/2020	Complement Inhibitor Therapy for Myasthenia Gravis.

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James F Howard Research Topics

Disease

36	Myasthenia Gravis 10/2021 - 11/2009
6	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2022 - 12/2011
4	Muscular Dystrophies (Muscular Dystrophy) 09/2015 - 08/2010
3	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 04/2015
3	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) 10/2018 - 11/2009
2	Polyneuropathies (Polyneuropathy) 06/2022 - 10/2018
2	Respiratory Tract Infections (Respiratory Tract Infection) 01/2022 - 12/2017
2	Muscle Weakness 05/2021 - 01/2018
2	Fatigue 08/2019 - 08/2019
2	Thymoma (Thymic Carcinoma) 12/2017 - 05/2017
2	Muscular Diseases (Myopathy) 11/2009 - 03/2003
1	Ataxia (Dyssynergia) 06/2022
1	Scoliosis 01/2022
1	Vomiting 01/2022
1	Demyelinating Diseases (Demyelinating Disease) 01/2022
1	Cough 01/2022
1	Neuromyelitis Optica (Devic's Disease) 01/2021
1	Nervous System Diseases (Neurological Disorders) 08/2019
1	Meningococcal Infections 01/2019
1	Headache (Headaches) 12/2017
1	Thymus Neoplasms (Thymus Neoplasm) 12/2017
1	Meningococcal Meningitis 12/2017
1	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 09/2015
1	Peripheral Nervous System Diseases (PNS Diseases) 04/2013
1	Autoimmune Polyendocrinopathies (Schmidt Syndrome) 04/2013
1	Contracture 02/2012
1	Pain (Aches) 02/2012
1	Weight Gain 12/2011
1	Obesity 12/2011
1	Morbid Obesity 12/2011
1	Pseudotumor Cerebri (Idiopathic Intracranial Hypertension) 12/2011
1	Polymyositis 11/2009
1	Stiff-Person Syndrome (Stiff Man Syndrome) 11/2009
1	Miller Fisher Syndrome (Fisher Syndrome) 11/2009
1	Guillain-Barre Syndrome 11/2009
1	Lambert-Eaton Myasthenic Syndrome (Lambert-Eaton Syndrome) 11/2009
1	Diabetic Neuropathies (Diabetic Neuropathy) 11/2009
1	Brachial Plexus Neuropathies (Erb's Palsy) 11/2009
1	Dermatomyositis (Dermatopolymyositis) 11/2009
1	Myositis (Idiopathic Inflammatory Myopathies) 03/2003
1	Multiple Acyl Coenzyme A Dehydrogenase Deficiency 03/2003

Drug/Important Bio-Agent (IBA)

16	Cholinergic ReceptorsIBA 10/2021 - 07/2013
14	eculizumab FDA Link 10/2021 - 07/2013
9	glucose-mannose-glucoseIBA 05/2021 - 01/2018
7	AutoantibodiesIBA 10/2021 - 11/2016
4	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022 - 03/2003
4	Phosphotransferases (Kinase)IBA 09/2021 - 04/2015
4	Complement Inactivating AgentsIBA 01/2020 - 12/2017
4	DystrophinIBA 02/2012 - 08/2010
3	muskIBA 09/2021 - 01/2019
3	Intravenous Immunoglobulins (IVIG)FDA Link 01/2020 - 11/2009
3	Rituximab (Mabthera)FDA Link 01/2019 - 09/2017
3	CytokinesIBA 01/2019 - 04/2013
2	deflazacortIBA 01/2022 - 12/2011
2	Prednisone (Sone)FDA LinkGeneric 01/2022 - 12/2011
2	Complement C5 (Complement 5)IBA 10/2021 - 05/2021
2	zilucoplanIBA 05/2021 - 01/2020
2	Immunoglobulin Fc FragmentsIBA 01/2021 - 01/2019
2	Pharmaceutical PreparationsIBA 01/2021 - 01/2020
2	Immunoglobulins (Immunoglobulin)IBA 01/2019 - 11/2016
2	Proteins (Proteins, Gene)FDA Link 01/2019 - 10/2018
2	SteroidsIBA 05/2018 - 07/2016
2	Complement System Proteins (Complement)IBA 01/2018 - 12/2017
2	AntibodiesIBA 05/2017 - 11/2016
2	Saline SolutionIBA 09/2015 - 02/2012
1	Riboflavin (Vitamin B2)FDA LinkGeneric 06/2022
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2022
1	InterferonsIBA 01/2022
1	LigandsIBA 01/2022
1	GlucocorticoidsIBA 01/2022
1	Immunoglobulin G (IgG)IBA 01/2021
1	AgrinIBA 01/2020
1	Interleukin-17 (Interleukin 17)IBA 01/2020
1	2-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA 10/2019
1	Tacrolimus (Prograf)FDA LinkGeneric 01/2019
1	neonatal Fc receptorIBA 01/2019
1	Circulating MicroRNAIBA 12/2018
1	PeriostinIBA 10/2018
1	Interleukin-10 (Interleukin 10)IBA 01/2018
1	Immunosuppressive Agents (Immunosuppressants)IBA 09/2017
1	Dihydrotachysterol (AT 10)IBA 09/2017
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 05/2017
1	VaccinesIBA 11/2016
1	Methotrexate (Mexate)FDA LinkGeneric 07/2016
1	Immunomodulating AgentsIBA 04/2015
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 04/2015
1	DNA (Deoxyribonucleic Acid)IBA 04/2015
1	Biomarkers (Surrogate Marker)IBA 02/2012
1	AcidsIBA 03/2003
1	LipidsIBA 03/2003

Therapy/Procedure

11	Activities of Daily Living (ADL) 01/2021 - 07/2016
7	Therapeutics 01/2020 - 02/2012
3	Plasma Exchange 10/2019 - 11/2016
2	Thymectomy 01/2019 - 12/2017
2	Analgesia 09/2015 - 02/2012
1	Denervation 06/2022
1	Continuous Positive Airway Pressure 01/2022
1	Punctures 02/2012
1	Anesthesia 02/2012